Zymessence:
The New Breed of Systemic Enzyme Blends
By: William
Wong ND, PhD, Member World Sports Medicine Hall of Fame
Those of you who know of my role in teaching
the applications of systemic enzymes these last 10 years know how I feel about
them:
"Systemic enzymes are the most important part
of maintaining a healthy body; of fighting the processes of both aging and disease;
and of undoing the planned obsolescence nature has built into our bodies to make
sure we don't stay on the planet for too very long.
Systemic enzymes are
the only nontoxic way of controlling inflammation of every type and from whatever
reason. More importantly, systemic enzymes are the only tools available in both
natural and allopathic (conventional) medicine for fighting fibrosis. (1, 2 etc.).
We have to remember that most all disease names end with one of two suffixes,
either the "itis" denoting an inflammation or an "osis" denoting
a fibrosis condition. Most of what winds up killing man is either an inflammation
(itis), such as heart and vascular disease, diabetes, cancer, trauma, Alzheimer's
or a fibrosis (osis) related event such as a clot caused stroke or heart attack;
fibrosis of the kidney, liver or heart valves; age related shrinking of the internal
organs; etc. (3) We also have to remember that of the two things that cause fibrosis,
inflammation is the #1 major thing that brings about the formation of fibrosis
and scar tissue. So control the one and you prevent the further formation of the
other."
My pilgrimage through the world of systemic
enzymes in learning and applying has been knowledge I've shared with anyone who
would listen to or read my work. Starting with the worlds first and most widely
known systemic enzyme product I became a "true believer" traveling to
Germany, learning of systemic enzymes with the enzyme makers there and helping
docs and patients Stateside in applying the work that had been researched and
proven in German medicine. With almost 200 peer-reviewed studies to prove absorption
and therapeutic action, systemic enzymes are an accepted pharmaceutical in most
of Europe and Asia (www.enzymescience.com).
So, after pouring over the
peer-reviewed studies and speaking to doctors about their clinical experience,
I began seeing the potential of systemic enzyme therapy and it became my passion
to bring that information to the rest of the world. And that's exactly what I
have been doing for the last 10 years. After just 2 years of teaching the myriad
of therapeutic applications of systemic enzymes to healthcare practitioners and
consumers worldwide, the sales of systemic enzymes (at that time) increased some
11,200% in the US. And from that came the realization of what systemic enzymes
could do and over 70 "new" systemic enzyme products popped up almost
overnight! It was fantastic.
Most of those 70 "new" enzyme products
were copy-cat-clones of the original "old school" German product, and
while some of them had first class (i.e. active) enzymes in them, some of them
did not. Still others were not clones of anything but completely "new school"
products based on more recent enzyme technology that allowed patients to have
stronger results while taking less product. Taking less of a product and gaining
good results was better than getting those results by having to take more and
I was sold on the "new school" systemic enzyme blends. In my personal
usage, given my numerous old injuries and chronic pain, I went from taking 45
to 60 of the older product daily to 20 to 30 of the newer enzyme blend. That was
cool!
During these last 10 years, we have applied systemic enzymes to
everything from simple osteoarthritis to auto immune conditions like RA and MS.
(4). In fibrosis conditions they were applied by docs for postoperative scar tissue
to Glomerulosclerosis of the kidney and to Pulmonary Fibrosis in the lungs. (5).
Plastic surgeons were even preventing the formation of scar tissue and kyloids
on their work! My teaching work reached even more physicians, patients and ordinary
folks who came to understand the physiology and uses of proteolytic enzymes and
the "new school" blends of systemic enzymes flourished. And again, more
copycat products cropped up almost overnight!
In time, as my knowledge
of systemic enzymes grew even further, I began to understand that there were advantages
and drawbacks to the "new school" blends of systemic enzymes just as
there were both with the "old". While both worked well, I felt that
the effects of the enzymes could be made better while at the same time taking
them could be made easier. As fibromyalgia / chronic fatigue, and chronic pain
patients know; even if it works, taking 20 to 30 of something a day can get to
be repulsive even if it's doing wonders for you. And so I started the quest for
a "new breed" of systemic enzyme blends.
It was with these thoughts
in mind that I had the pleasure to meet with an old and very experienced hand
at creating enzyme formulas. This fellow is a German trained pharmacologist very
experienced in the making of systemic enzyme blends. Having the experience of
working at Bavarian pharmaceutical companies and making products for the demanding
German and Swiss pharmaceutical markets, this gentleman is very well versed in
all of the aspects of both making pharmaceutical grade products (the highest grade
of drug, herb or supplement product you can use), as well as creating the ways
of making that product both absorbable and physiologically effective. Because
we are, after all, not what we eat but what we absorb and utilize.
With
this PhD's guidance, I related what I wanted an enzyme product to do and what
I would like to see in it. He took my ideas, made suggestions and developed a
comprehensive systemic enzyme that filled all of my goals and then some:
1. I wanted my systemic enzyme product to be persistent. In other
words, to have a long lasting effect in the body. German medical research shows
that animal based systemic enzyme blends stay in the body working for 24 to 36
hours. While Indian pharmaceutical research shows that the purely vegetable based
enzyme blends stay active in the body only some 4 to 6 hours. (6,7). So with apologies
to my vegetarian friends, our new enzyme blend contains highly active animal based
pancreatin instead of the vegetable imitations of pancreatic enzymes. This will
ensure "persistence" which is one way of being able to lower the dose
that needs to be taken. My experience and the experience of my pharmacologist
friend also is that since humans are animals (not vegetables), real animal pancreatin
does indeed absorb better and work better than the pancreatin imitations from
vegetable sources.
Now, not all pancreatin is equal. Most products containing
animal based pancreatin are dilutions from the full strength pancreatin which
is 12 to 14X. Pancreatin is diluted by cutting it with lactose (milk sugar) until
the desired dilution is achieved. According to the US Pharmacopoeia (the US formulary
for pharmaceutical grade products) 1X USP has the ability to:
- Digest
25 times its weight in carbohydrates
- Digest 25 times its weight in proteins
-
Digest 9 1/2 times it weight in fats.
If 1 X USP pancreatin can do
that, then 12 to 14X USP will do 12 to 14 times the work! Usually 4X is the lowest
dilution found in enzyme blends and finding a product with 10X is rare, though
there are some. For my Zymessence only full strength undiluted 12 to 14X Pancreatin
is used.
The added advantage of using a non-diluted pancreatin aside from
its strength is that there is no lactose in the product to cause stomach upset
in those who are lactose intolerant nor will it interfere with the enzyme activity
of the Amylase in the product.
2. In my private conversations
with the late Dr. Karl Ransberger, an enzymologist I admired and held up on a
pedestal, he related to me that the most important enzyme in a systemic enzyme
blend was not the one in the highest quantity but the enzyme with the greatest
ability to lyse (eat) away at fibrin; this action is called fibrinolysis. He told
me how in enzyme blends the strongest fibrinolytic enzyme acts as the director
or a general enhancing the action of all of the other enzymes and targeting their
action. So, while part of the Zymessence formula would contain a powerful undiluted
animal pancreatic enzyme which naturally contains trypsin and chymotrypsin normally
found in pancreatin, I wanted to make the strongest fibrinolytic enzyme commercially
available, serrapeptase, a part of the formula. Serrapeptase according to the
Handbook of Proteolytic Enzymes is 5 to 8 times stronger a fibrin eating enzyme
than chymotrypsin. And, while I wanted a good stiff amount of serrapeptase in
the blend, its milligrams per dose are not as important as its true enzyme activity.
Most enzymes sold are the lower-class food grade products and don't have a
lot of activity, while higher-class pharmaceutical grade enzymes are an assurance
of an enzyme working.
3. Next, I wanted a systemic enzyme
product with my brand name on it to be so strong that folks could take a much
lower dose than they had previously needed to take of other products. With the
undiluted, full-strength pancreatin in each of our Zymessence caplets equal to
1530 mg of USP enzymatic activity, when you then add the strength of the serrapeptase
and fruit enzymes over and above that, milligram per milligram 1 Zymessence caplet
is substantially stronger than 3 or more capsules/tablets of any other systemic
enzyme blend available at present.
But, since milligrams don't really
mean much in systemic enzyme blends anyway and activity can only be determined
by use, I always say: "The proof of any pudding is in the eating." When
I personally tested samples of Zymessence I found its action felt much greater
than the "milligram numbers" would suggest: I'm now able to achieve
with 3 caplets a day of Zymessence what I used to have to take 30 capsules daily
of one product or 60 tablets a day of another!!! While testing the new product,
my wife would catch me reaching, stooping and doing things I would have normally
winced at or just couldn't get myself to do at all!
Most Zymessence
users will find their dosing range between 3 and 6 caplets per day. So a bottle
of 180 enteric matrix caplets will last 1 to 2 months. Only if you have a building
fall on you or survive a parachute failure in a skydive should you ever need to
use 9 or more caplets a day. Mind you, I am not saying 3 to 6 caplets a few times
a day as with other products, I'm saying 3 to 6 caplets total per day tops!
As most customers who have used systemic enzymes know, the dose recommendations
on the label for most products are not what actually works for reducing inflammation
or fibrosis; the suggestions are just there for show as actual working or "Activation
Doses" are much higher. The suggested use recommendations on Zymessence are
what will actually work. Period.
4. Finally, delivery
of the enzymes had to be shielded against stomach acid destroying its action so
some sort of enteric protection had to be put into the product. Having dealt with
enteric coated and non-enteric coated enzymes for a decade, I've come to the conclusion
that even when the enzymes are cultured to withstand acids, these enzymes are
absorbed better and have a stronger action when they are protected against stomach
acid. An enteric coating protects things from acids. Acids can destroy some enzymes;
real animal based pancreatin and the serrapeptase's specifically, as acid
resistant forms of those enzymes have not yet been developed. In most products,
the protective enteric coating is just that, a coating on the outside of the tablet
or capsule. The problem there is that if the tablets get jostled, bumped or dropped
(as can easily happen inside bottles) and the coating is scratched, nicked or
otherwise compromised, then it will fail and the enzymes inside will be harmed/killed-off-in-part
by the stomach acids. Here is another place where my pharmacologist friend shines!
Using his German pharmaceutical knowledge, my pharmacologist friend has made the
enteric coating run throughout the Zymessence caplet (oval shaped tablet). So,
the coating is not only on the outside but runs through the inner beads that compose
the caplet (micro-encapsulation), insuring against enteric coating failure. Again,
this makes for more enzyme activity getting inside of the intestines where it
is safe and alkaline. Once there, the enzymes are absorbed and taken throughout
the body.
So based on our own needs, public demand and our clinical and
professional experiences, we now present Zymessence: The only systemic enzyme
blend of its kind. Made to exacting standards in a pharmaceutical grade manufacturing
facility that is FDA certified as well as certified by the Swiss and German governments
to make pharmaceutical medicines for their nations! (German and Swiss pharmaceutical
manufacturing and purity standards are higher than those of the FDA's).
With over a half century of collective experience in enzyme making, therapeutic
action and clinical application that my pharmacologist friend and I have brought
together, I proudly bring you: Zymessence. I believe Zymessence is the finest
systemic enzyme product made. But, since the proof of the pudding is in the eating,
try one bottle of Zymessence and feel the difference.
References:
1a) Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent
in emergency surgery. Arztl. Praxis 24 (1972), 2307.
1b) Mazzone A, et
al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology
pathology: a multicentre, double blind, randomized trial versus placebo. J Int
Med Res. 1990; 18(5):379-88.
1c) Kee W., H. Tan S, L., Lee V. Salmon Y.
M.: The treatment of breast engorgement with Serrapeptase: a randomized double
blind controlled trial. Singapore Med J. 1989:30(l):48-54.
1d) Enzymes
ñ A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published
1993 Eco Med.
2) Kakinumu A. et al.: Regression of fibrinolysis in scalded
rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
3) http://www.totalityofbeing.com/FramelessPages/Articles/FibrosisEnemyArt.htm
4) Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of
proteases in immune complex decomposition and formation. First International symposium
on combination therapies, Washington, DC, 1991.
5) Heidland A., Sebekova
K., Paczek L., Teschner M., Daemmrich J., Gaciong Z.: Renal fibrosis: Role of
impaired protein degradation and potential therapeutic strategies. Medical Faculty,
University of Wuerzburg, 2 Institute of Preventive and Clinical Medicine, Bratislava
(Slovakia), 3 The Transplantation Institute Warsaw (Poland), 4 Institute of Pathology,
University of Wuerzburg (Germany). Kidney International 1997, Vol. 52, Suppl.
62, pp. S 32- S 35 343 KA (5-08-3).
6) Oral Enzymes, Basic Information
and Clinical Studies, published by Mucos Pharma, 1992, page 28.
7) Exclzyme
EN, Clinical Efficacy, Dr. V. Patki, Clinical Pharmacologist http://www.enzymescience.com/
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WAM
Essentials, Zymessence
