This report presents the results of toxicology, cell proliferation, and efficacy testing work carried out on natural and synthetic humic acids by contract laboratories of the Virology Branch of the Antiviral Research and Anti-microbial Program, Division of Microbiology and Infectious Diseases, National Institutes of Allergy and Infectious Diseases under the auspices of the National Institutes of Health (NIH). Dr. Christopher Tseng, Program Officer, performed the Laboratory work at the NIH labs in Bethesda, Maryland, from August 2001 to January 2002.
Antiviral properties were examined on herpes, influenza, chicken pox/singles, mononucleosis, and hemorrhagic fevers (Ebola). Additionally, commonly used drugs for the respective diseases were tested for comparison.
Standard toxicity tests were run on both the natural and synthetic humates used in the tests. Both compounds evaluated were not toxic at levels at least as high as 100 ppm as indicated in the table below. The humate compounds were found to bind to cell surfaces, thereby changing their color but were in no way toxic to the cell.
|Monkey Kidney||Human Foreskin||Dog Kidney|
Cell Growth Effects
Testing was done on both compounds to see if any effect was observed on normal cell growth of health tissues. Observations from the tests indicated no ill effect on cell growth or reproduction.
|Human Foreskin||CP50 ppm|
|Burkettâ€™s lymphoma Cells|
Herpes simplex virus types 1 and 2 are responsible for fever blisters and genital herpes, respectively. Approximately 45 million Americans are serum-positive for genital herpes (type 2). It is further believed that 80% of Americans are serum-positive for (type 1) with all exhibiting occasionally symptoms.
Human cytomegalovirus (HCMV), a virus that weakens the immune system, is present in 50% of the rural and 90% of the urban population of the US.
Varicella Zoster virus (Chicken Pox/Shingles) is present in most of the US population and is most generally contracted during the young years a Chicken Pox and returns later in life as Shingles.
Epstein-Barr virus (mononucleosis) is the cause of infectious mononucleosis and adolescents and young adults.
The common drugs of choice for these classifications of diseases are Acyclovir and Ganciclovir. Below are the test results for the effectiveness of humates against the virus along with preferred medications for comparison.
Effectiveness of humates with herpes/associated viruses in ppm.
|Type 1||Type 2||Shingles|
|Synthetic HA 6||6.2||28.2||>100||>0.4|
Influenza A and B viruses are routinely responsible for 20 000 to 30 000 deaths annually in the U.S. and well over 100 000 hospitalizations. From time to time variations/mutations of the virus affect many people. The 1918 Spanish Flu caused approximately 500 000 deaths in the U.S. The 1957 Asian Flu 70 000 deaths and the 1968 Hong Kong flu 34 000.
The effect of natural and synthetic humates on differing types of flu virus are listed in Table 4 along with the effectiveness of the most common drug Ribavirin. Additional testing on live animals indicated the humates possessed some prophylactic effects on the viruses.
Effects on flu virus by humates by dosage in ppm
|Flu Type||Synthetic Humate Natural Humate|
|Type A (NWS/33)||1||1.3||6|
|Type A (PR/8/34)||8.5||14||9|
Hemorrhagic Fever Viruses such as Ebola and Hanta Virus.
The two viruses examined from this classification were the Pichinde Virus from South America whose members are generally associated with rodent-transmitted disease in humans. Punta Toro Virus is also a South American virus normally transmitted by sand flies. Crimean-Congo Rift Valley Ebola and Hanta viruses are also members of this family.
The effectiveness of the humates with the hemorrhagic fever viruses examined in this work are provide in the following table along with the drug Ribavirin which is used many times in the treatment.
Testing also indicated that the humates taken before introduction of the virus exhibited strong prophylactic effects.
Humate Effectiveness with Hemorrhagic Fever Viruses in ppm Dosages
|Pichinde Virus||Punta Toro Virus|
Humates are exhibiting effects both as a preventative and a curative for a broad range of viruses. Both the synthetic humate and well as the natural are demonstrating good effectiveness and in some case exceeding the drugs of choice.
Natural humates are readily available non-prescription and inexpensive materials that have effectiveness on both animal and humans.
This paper is a summation. The text of the entire 43 page report can be obtained from www.laubbiochem.com. Go to the science section and 2001-2002 data. In this report natural humate (Terratol) is called Hepsyl HA. All other Hepsylâ€™s are synthetic compounds.
Asthma and Lung
Asthma and lung infections on the rise in all age groups
Asthma is a chronic inflammatory disease of the airways. When not diagnosed or properly treated asthma can lead to a host of social and financial problems.
Hospital studies show that the common cold and related bronchial asthma and respiratory illnesses from infection can be rapidly cured when patients are treated with fulvic acid. Especially pleasing to parents is the powerful and immediate effect this therapy has on young children. Erchuan Wang et al Humic acid 3 (1991)
New research by Dr. David L. Hahn of Dean Medical Center Madison Wisconsin shows that pneumonia related respiratory disease and acute bronchitis caused by chlamydia pneumoniae appear to be the cause of most asthma. His recent studies show that asthma patients have been found to have a high level of antibodies for chlamydia pneumoniae which seems to be a common denominator among asthma sufferers. Dr. Hahn believes that chlamydia antibody detection can be an effective tool in diagnosing asthma.
In hospital studies profuse otherwise unstoppable bleeding of the mucous membrane of the nose mouth throat bronchial and lung areas related to acute respiratory and viral infections in patients with tuberculosis heart failure leukemia and other serious diseases were successfully stopped with fulvic acid therapy.
Suchen Cao Jiangxi Humic Acid 3 (1993)
Extensive research of HMO studies conducted from 1967-1987 showed that “prevalence of asthma increased steadily and significantly…in both males and females in all age ranges.” These findings were reported in the April 1998 issue of the American Journal of Respiratory and Critical Care Medicine. Although the data in those studies do not go beyond 1987 then researchers found that “more recent national data suggest that these increases are continuing.” The weight of the evidence for an ongoing rise in asthma they conclude “is growing steadily.”
Hospital studies showed that serious and acute cases of chronic bronchitis were better treated and cured with fulvic acid (96.77% cure rate) that worked significantly better than conventional drug therapy. Symptoms of inflammation coughing sputum and asthma were also much better alleviated.
Jingrong Chen et al Jiangxi humic acid 2 (1984)
Speaking for the American Academy of Allergy Asthma and Immunology Dr. Gary Rachelefsky said: “Despite the fact that we have a real understanding of the disease and medications to treat it we still have increased asthma.” About 7% of the children in the US have asthma. The prevalence has increased 40% between 1982 and 1993. It is the most common childhood disease and is the top reason for pediatric hospitalization accounting for up to 300 000 admissions a year. Asthma is the cause of 10-30 missed school days per asthmatic child per year. Asthma effects over five million U.S. children and adolescents and accounts for 28% of all direct medical expenses totaling nearly $5 billion in spending per year.
Ann Allergy Asthma Immunol 2000;84:227-233. Am J Respir Crit Care Med 1998;156:36-42.
Johns Hopkins PR Newswire and Reuters news services; Summaries of interviews and meetings of the AAAAI; April and May 1998
Arthritis Autoimmune Diseases
Arthritis related autoimmune diseases including Lupus Fibromyalgia and Rheumatoid Arthritis; Humic substances offer hope.
An estimated 40 million Americans have some form of arthritis or other rheumatic condition. That number is expected to climb to 59.4 million or 18.2 percent of the population by the year 2020.
In a recent issue of Annals of Rheumatic Diseases doctors found that people with rheumatoid arthritis have lower levels of common antioxidants in their blood in the years before the disorder is diagnosed. A new study suggests that the same may be true for another autoimmune disease systemic lupus erythematosus. It is not certain if the lower level of antioxidants is a cause or the effect of the diseases or indirectly related to the disorders.
According to Dr. George Comstock of the Training Center for Public Health Research in Hagerstown Maryland antioxidants in the blood are possibly being used to mop up damaging free radicals byproducts of inflammation related to the diseases. “Or perhaps low antioxidant status whether because of decreased intake absorption or transport increases the potential for oxidative damage he wrote.
Humic extracts especially fulvic acids when administered both topically and orally are proven to regulate the immune system as powerful immunomodulators and to work as potent antioxidants and anti-inflammatory agents. In studies with hospital patients with rheumatoid arthritis an autoimmune disorder humic extract bath therapy treatment had a 92% success rate. Several hundred similar studies have been performed in China showing that fulvic acid and humic extracts are proven highly successful.
Yuan Shenyuan; Fulvic Acid 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June 1993
Ghosal Shibnath. Chemistry of shilajit an immunomodulatory Ayurvedic rasayan. Pure & Appl. Chem. vol. 62 1990 No. 7 pp. 1285-1288.
Rheumatoid arthritis is more prevalent in women than in men and generally strikes between the ages of 20 to 40. It is believed to be caused by an abnormal immune reaction in which the lining of the joints are attacked and destroyed leading to pain inflammation swelling and eventually deformity of the joints and disability. Approximately 1 percent of U.S. adults have definite rheumatoid arthritis an autoimmune disease occurs more frequently in women than in men. The prevalence of rheumatoid arthritis is approximately 2.1 million people: 600 000 men and 1.5 million women.
The estimated U.S. prevalence of juvenile rheumatoid arthritis (JRA) which occurs in children ages 16 and younger is between 30 000 and 50 000.
For the new study Dr. Comstock and colleagues looked at thousands of blood samples donated in 1974 and specifically tested those from 21 people who were diagnosed with rheumatoid arthritis 2 to 15 years after giving blood. They also identified another six people who developed systemic lupus erythematosus 3 to 13 years after giving blood.
Lupus is also thought to be due to an abnormal immune reaction in which the body attacks connective tissue and numerous organs. The disease is 10 times as common in women as men and most often occurs between ages 13 and 45. Comstock mentioned in the article that the trend does match that of an earlier small study which suggests that low concentrations of antioxidants may in some way be related to the development of rheumatoid arthritis either directly or as associates of another disease-causing factor. “Although the number of cases is too small to allow definitive statements about the association of serum antioxidants with systemic lupus erythematosus it is hoped that this report will stimulate others to see if our results can be replicated he wrote. Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease in which the body harms its own tissues and can lead to inflammation and damage to joints skin kidneys heart lungs blood vessels and the brain. Reports estimate SLE to affect at least 239 000 Americans: 4 000 white males 41 000 white females 31 000 black males and 163 000 black females.
The autoimmune disorder Fibromyalgia affects an estimated 3.7 million Americans age 18 and older. Prevalence is much lower in men than in women. A chronic condition fibromyalgia is characterized by widespread pain greater sensitivity to pain sleep disturbances fatigue and multiple tender points.
Johns Hopkins News Services; A report published as a collaborative effort between the National Institutes of Health (NIH) the Centers for Disease Control and Prevention (CDC) the Arthritis Foundation and the American College of Rheumatology; May
1998. Annals of Rheumatic Diseases (1997;56:323-325).
Cancer is second leading cause of death in the US humic extracts arrest cancer growth according to medical studies
According to the National Cancer Institute about 1 228 600 new cancer cases were expected to be diagnosed in the year 2000. Since 1990 approximately 11 million new cancer cases have been diagnosed.
In the year 2000 about 564 800 Americans were expected to die of cancer more than 1 500 people a day. Cancer is the second leading cause of death in the U.S. exceeded only by heart disease.
Patients with cancer-causing tumors of the esophagus had 100% success rate in preventing tumor progression into the cancerous state when treated for two years with a humic extract solution.
Yuan Shenyuan; Fulvic Acid 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June 1993
One of every four deaths in the U.S. is from cancer. Since 1990 there have been approximately 5 million cancer deaths. Overall annual costs for cancer run $107 billion per year.
Breakthrough cancer research studies supported by the National Institute of Health clearly indicate that oxygen-containing molecules known as oxidants or free-radicals play an important role in causing cancer and that antioxidants or free-radical scavengers help suppress cancer.
In a surprising new development the study shows that cancerous cells themselves are causing an overproduction of free-radicals. This alone can account for cancerÃs typical runaway cell growth.
Cancer cells have now been shown to produce oxidants that act as messenger molecules and send signals through protein pathways bombarding surrounding cells uncontrollably
The study shows that certain super antioxidants work to obstruct the signaling protein pathways neutralizing the spread of cancer and can potentially prevent it in the first place. Unique protein inhibiting antioxidants block the necessary signals that normally allow adjacent cells to become cancerous. Studies point to antioxidants as new anticancer treatment and prevention strategies. Humic extracts (Fulvic acids) are nature’s most powerful antioxidants. Pharmacological studies throughout the world have shown that various mechanisms within the humic molecular structure make it both a donor and acceptor free radical scavenger and antioxidant. Also noted are powerful superoxide dismutases (SODs) and metalloenzymes of every conceivable kind.
While all humic extracts do not always destroy cancer cells they generally halt their growth and spread. Sometimes tumors disappear almost immediately and spontaneously. Humic extracts are certainly cancer preventative and it is certain that the higher the quality of humic extract the better the ability to reverse and completely cure cancers.
Outpatient medical hospital studies on thyroid tumors some cancerous showed that injections with a special humic extract were 90% successful in stopping tumor growth and diminishing size of tumors with 80% of patients having complete cures.
He Shenyi et al; Humic acid in Jiangxi Province 1 (1982)
It has been found that naturally-occurring humic acid preparations can stimulate the production of cytokines including interferon-gamma interferon-alpha interferon-beta and tumor necrosis factor-alpha. What this means is that a valid mechanism has been discovered proven and documented whereby humic extracts are able to work with the body to selectively seek out and destroy cancer cells.
Statistics from the National Cancer Institute.
Irani K; Xia Y; Zweier JL; Sollott SJ; Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts; Science; 1997
March 14; 275 (5306):1649. Pennisi E; CELL BIOLOGY: Superoxides Relay Ras Protein’s Oncogenic Message; Science; 1997;
March 14; 275 (5306):1567.
Reactive oxygen and cell proliferation; Science; 1997; March 14; 275 (5306):1541.
Visser S.A; Effects of humic substances on higher animals and man; the possible use of humic compounds in medical treatments;
1988; which was presented at the International Humic Substances Society meeting in Sevilla Spain.
Yuan Shenyuan; et al; Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June
Inglot AD; Zielinksa-Jenczylik J; Piasecki E; Arch.Immunol. Ther. Exp. (Warsz) 1993 41(1) 73-80)
Blach-Olszewska Z; Zaczynksa E; Broniarek E; Inglot AD Arch. Immunol. Ther. Exp. (Warsz) 1993 41(1) 81-85).
Cancers are Viral
Common Virus Shows Link To Brain Cancer In Children Colon penile uterine cervical liver and numerous other cancers are also caused by viruses
February 21, 2002
A new study appearing today in the Journal of the National Cancer Institute shows that the JC Virus (JCV) which infects about 65% of children by age 14 likely plays a role in the development of the most common type of malignant brain tumor found in children. This finding is consistent with many other recent reports linking viruses to cancer. The JC Virus is named after a patient John Cunningham from whom the virus was first isolated in the 1970’s. According to the senior author of the study Dr. Kamel Khalili the JC Virus “is very common and he went on to say that “sixty-five to 70 percent of human populations worldwide get infected with this virus by age 14 so we all basically have this virus in our bodies.”
Twenty specimens of brain tumors taken from children showed evidence of the JC Virus. Dr. Khalili says that “the presence of the virus… is suggestive of a biological role for this virus in the development of these tumors.”
Khalili who is a cancer researcher at PhiladelphiaÃs Temple University said that earlier lab studies show that the JC Virus causes cancer in rats mice and brain tumors in certain monkeys.
The JC virus comes from a viral group called Neutropic Polyomaviruses. It usually infects the upper respiratory system by inhalation of airborne particles just like the common cold. Polyomavirus caused respiratory infections are very common in children. The virus causes no serious disease unless a personÃs immune system is weak. In patients with very weak or destroyed immune systems (such as AIDS patients or those who are taking organ anti-rejection drugs) according to Dr. Khalili the JC Virus can cause progressive Multifocal Leukoenchephalopathy (PML) a fatal brain disease. Dr. Khalili says that evidence suggests that JC Virus also plays a role in the development of the most common brain cancer in children medulloblastoma. This type of cancer is diagnosed annually in about one out of every 200 000 children under the age of 15. It is a very aggressive cancer that is difficult to treat and often is fatal. Dr. Khalili says that if it can be conclusively proven that JC virus does play role in the brain cancer, then it may be possible to develop a vaccine that could help in treating the tumor or preventing its spread.
Studies by Dr. L. Laghi and associates have shown that JC Polyoma Virus also causes colon cancer. In other extensive research Dr. Richard C. Hunt at the University of South Carolina has documented many other viruses as the cause for colon penile uterine cervical liver and numerous other cancers.
This information provides support for the idea that humic substances (fulvic acids) are a little-known and important missing link throughout the food chain. Modern agricultural practices have eliminated the humic substances from farm soil which parallels increases in viral plant animal and human viral infections. Common to rich organic soil humus fulvic acids have been shown to have unequalled value in defending plants animals and man against viruses of all kinds and also in significantly increasing and balancing immunity. Of interest is also the fact that hospital studies in China showed that children with serious respiratory infections responded exceptionally well to humic – fulvic extracts when nothing else seemed to work.