I started taking Opti-MSM when began my wellness journey. I do believe that it helped me heal from an ankle injury, according to my chiropractor. When he heard I had been taking it and I no longer had pain in that area, he was the one that said it was likely due to taking that supplement. I worked my way up in my dosage and I'm sure that was a contributing factor. I've re-ordered it once and will do so again when I'm getting low.