I've been on Serrapeptase almost a year bc it absolutely changed my life. At first I took 8-10 doses a day for 2 weeks , 6-8 doses a day for the next 2 weeks, 4-6 doses a day the next 2 weeks, 2-3 doses a day the next 2 weeks, and then only 1 dose a day. Since then there have been times I've had to take 2-3 doses a day for a week or so such as when I got the flu shot. I've missed taking it a few days and by the end of day 2 my pain is returning. I'd rather starve to death than not have this bc life is not worth living without it. I won't even try another brand bc the pain isnt worth it. THIS IS NOT A PAID ADVERTISEMENT.