10 Reasons to Choose AstaREAL® (natural Astaxanthin)
1. The Most Studied Natural Astaxanthin
AstaReal has sponsored a large number of efficacy studies including over 40 clinical studies conducted all over the world.
2. The Safest Natural Astaxanthin
AstaReal sponsored over 40 safety reports including a large number of clinical studies with subjects undergoing treatments lasting from 2 weeks to 6 months.
3. Breadth of Intellectual Property
AstaREAL® is the leading brand of patents related to the use of astaxanthin for human health.
4. Health Professional Recognition
AstaREAL® astaxanthin has been endorsed by internationally acclaimed dermatologists, ophthalmologists, urologists, internists, endocrinologists, cardiologists and nutritionists.
5. Athlete Recognition
AstaREAL® astaxanthin has been endorsed by leading triathletes, Olympic medalists, trail runners, track runners, racing drivers, volleyball, baseball and football players.
6. Leading Brand Recognition
AstaREAL® astaxanthin has been formulated in numerous high profile supplements and cosmetic brands in Europe, North America, Southeast Asia, India and Japan.
7. Animals Expert Recognition
AstaREAL® astaxanthin has been endorsed by leading horse trainers, sled dog racers and veterinarians.
8. Pharmaceutical Manufacturing Expertise
AstaREAL® astaxanthin quality is based on Fuji Group’s expertise in pharmaceutical industry that spans six decades.
9. Product Research & Development
AstaReal® boasts one of the most powerful R&D teams in the industry. Our development of unique and pioneering applications of astaxanthin for human health include many milestone breakthroughs, such as water solubility for use in functional beverages.
10. Pioneer in Microalgae Biotechnology
AstaReal® was the first company in the world to commercially produce natural astaxanthin from Haematococcus pluvialis. AstaREAL® products are backed by the highest expertise and longest experience in the field of microalgae research and production.
How does Astaxanthin compare to other antioxidants?
All antioxidants have the same action - neutralizing harmful ROS by quenching or scavenging action. The potency determined by in-vitro tests can indicate the antioxidant capacity. When compared properly, antioxidant potency can vary tremendously. For example: Astaxanthin Singlet oxygen quenching activity in a lipid and water soluble system (Nishida et al., 2007)
- 6000 times stronger than Vitamin C
- 3000 times stronger than resveratrol and quercitin
- 800 times stronger than CoQ10
- 560 times stronger than epigallocatechin-gallate
- 75 times stronger than alpha-lipoic acid
How does Astaxanthin work?
Astaxanthin is a lipid soluble carotenoid antioxidant. Upon ingestion astaxanthin can be found in all organs of the body. At the cellular level astaxanthin accumulates in the membranes of cells and in the membranes of mitochondria and many others. Astaxanthin has a unique structure that enables the molecule to span the double layer membrane and consequently, exposes itself both to the interior as well as the exterior of the cell. By localizing itself in the membranes, astaxanthin protects membrane components like proteins and unsaturated fatty acids from ROS mediated oxidation. Furthermore, this high antioxidant capacity can inhibit the activation of the proinflammatory response via the NF-kB dependent pathway.
Irreplaceable Molecule for any Anti-Aging Regimen
When a shrimp is cooked, it suddenly turns red. The red color is Astaxanthin- a carotenoid xanthophyll that tints salmon, crab, krill and lobster with vivid reddish pigmentation. The rising popularity of astaxanthin as anti-aging nutraceutical supplementation and cosmeceutical application has been endorsed by acclaimed researchers, health specialists and professional athletes worldwide as well as being featured in many nutritional regimens in popular mass media.
Astaxanthin is Mother Nature’s Most Powerful Anti-aging Molecule
Strongest Singlet-Oxygen Quencher among anti-aging molecules.
- 6000 times stronger than Vitamin C
- 800 times stronger than CoQ10
- 550 times stronger than Green Tea Catechins
- 550 times stronger than Vitamin E (a-tacopherol)
- 75 times stronger than Alpha Lipoic Acid
- 40 times stronger than Beta-Carotene
- 17 times more potent than Grape Seed Extracts
- Potent antiperoxidative membrane activity
- Inhibits NF-kb inflammatory Gene expression
- Suppresses DNA damage (8OHdG)
Protective Effect of Natural Antioxidants on Human Fibroblasts Astaxanthin vs. other antioxidants.
Human dermal fibroblasts were pre-incubated with antioxidants before exposure to singlet oxygen, and cell viability was measured to compare the protective efficacy.
Purest antioxidant molecule because it has no proxidant activity even when subjected to enormous amount of stress from environmental factors and free radicals.
Provides a unique membrane protection because with its longs chain structure and polar end groups can span the bilayer membrane incrementing resilience against oxidative stress. Astaxanthin quench free radicals both in the water and fat loving zone of the membrane in contrast to most antioxidants, which work either in the inner (Vitamin E and Beta Carotene) or outer (Vitamin C) side of the membrane.
Provides superior mitochondria protection as research shows that is 1,000 times more effectively than Vitamin E against lipid peroxidation in the mitochondria.
Synergies and protect our endogenous antioxidants from early degradation.
Reduces DNA Damage and premature cell death caused by oxidation and plasma C-reactive oxygen .
Crosses brain-retinal blood barrier leading to neuro-protective effects and alleviation of eye fatigue.
Powerful Anti-Inflammatory - Several in-vitro and in-vivo studies shows that ASX strongly suppressed nuclear translocation of NFkB inflammatory cascade, which are the leading cause of most degenerative diseases.
Astaxanthin - Clinical Benefits
The Global Burden of Cardiovascular Disease
- Improves blood lipid profile
- Reduces oxidative stress
- Enhances capillary circulation
Cardiovascular diseases (CVDs), including heart attack and stroke, are the leading cause of death globally. According to WHO, 17.3 million people died from CVDs in 20081. Of those, an estimated 7.3 million deaths were due to coronary heart disease and 6.2 million were due to stroke.
Behavioral risk factors such as smoking, unhealthy diet, and alcohol abuse are believed to be responsible for 80% of coronary heart disease and cerebrovascular disease2.
Moreover, these behaviors result in increased body weight, elevated blood pressure, dyslipidemia, insulin resistance, and hyperglycemia. These effects are associated with the development of atherosclerosis, which is the main underlying cause of heart attack, stroke, and peripheral vascular disease.
Oxidative stress and inflammation are widely recognized as contributing factors to atherosclerotic CVDs. The use of antioxidants such vitamin E, C, and beta-carotene as preventive therapies for CVDs has yielded mixed results. This is why astaxanthin, which is a much stronger antioxidant that also exhibits anti-inflammatory properties, is now being investigated as a promising compound for protecting against atherosclerotic CVDs. Studies have shown that natural astaxanthin reduces oxidative stress and inflammation, improves lipid profiles, promotes better blood flow in capillaries, and lowers blood pressure in hypertensive individuals. Importantly, no adverse effects have been reported in these studies.
A large body of clinical and experimental research strongly suggests that astaxanthin can contribute to improved cardiovascular health. For more details on how natural astaxanthin can help support and maintain good cardiovascular health, please contact us for an expanded version of this digest.
A Hidden Pandemic: Computer Vision Syndrome
- Relieves eye fatigue symptoms by improving capillary blood flow circulation
- Improves quality of vision by preserving the “zoom-in & zoom-out” refocus of the eye ciliary muscle
- Relieves eye inflammation and shoulder stiffness in heavy PC workers
On average, workers and adolescents in modern cities spend over 45 hours every week staring at computer screens, playing video games, watching television, or interacting with smart phones. The U.S. National Institute of Occupational Safety and Health found that over 88% of office workers report eyestrain. A European study showed that 23% of Swedish schoolchildren experience eye fatigue due to playing video games excessively. This widespread use of visual displays increases stress on the eyes, which leads to a complex ophthalmic and psychophysical condition called computer vision syndrome (CVS). Symptoms of CVs include eye strain, sensitivity to glare, sore eyes, blurred vision, and neck and shoulder pain. CVs also causes mood swings, irritability, physical burnout, headaches, and a consequent decline in mental performance, motivation, and interpersonal efficacy.
Reveal Your Skin’s Natural Beauty with Astaxanthin
- Revitalizes photo aged skin by quenching oxidative stress and inflammation in all skin layer
- Reduces the size of wrinkles and improves skin microtexture
- Lightens age spots by inhibiting overproduction and oxidation of melanin
When wrinkles or skin problems arise, most women reach for cosmetic products, like creams, gels, ointments, and makeup. Applying these products to the surface of the skin may temporarily conceal the problem, but their effect is superficial and doesn't tackle the underlying causes. The skin is an extremely complex organ, consisting of multiple layers that each have unique and important functions. For a product to truly improve the skin’s health and beauty, it must provide protection and support to all layers of the skin.
Our skin is under constant attack from free radicals produced by UV rays, pollution, stress, and poor nutrition. The damage caused by free radicals is a major cause of skin aging and problems such as wrinkles and age spots. This free radical damage affects all layers of the skin, from the visible surface to the delicate deep layers where new skin is formed.
Natural algae astaxanthin is a powerful antioxidant with potent anti-inflammatory effects. Its unique molecular structure allows it to reside in the cell membrane and to protect the inside and outside of cells from free radical attack. Research shows that astaxanthin taken as an oral supplement is active in each of the skin’s layer, provides protection from UV damage, shrinks wrinkles, and makes age spots smaller. Natural algae astaxanthin can help your reveal your skin’s natural beauty from the inside out.
Physical Performance and Muscle Function
- Boosts power output and Muscle endurance during training
- Lowers lactic acid, fatigue, and muscle soreness
- Reduces muscle damage and inflammation
- Improves blood flow and antioxidant status
- Muscle metabolism improves fat utilization
More than ever, people nowadays enjoy a wide variety of sport activities to maintain a healthy body weight and circulatory system. From lifestyle changers to elite athletes, fastidious training may not always bring desired results. Some may experience performance slumps or a decline of endurance. Specialized nutritional support is recognized to support physical performance in many ways. From isotonic drinks to protein and carbohydrates, natural astaxanthin nutritionally completes the demands of a physically active lifestyle.
During our physical activity, we require energy to move our body. And all energy we need are generated by mitochondrial cells, often referred to as the “power stations of the cell”, which provide as much as 95% of our body’s pure energy (primarily by the burning of muscle glycogen and fatty acids). Unfortunately, a portion of this energy produces highly reactive and damaging reactive oxygen species (ROS) which is the one of major factors to deteriorate our body. ROS leads the cause of cell damage by peroxidation of the cell membrane components, and oxidation of DNA and proteins. What we found from numerous studies and research, ROS also caused the inflammation of muscle tiredness and soreness. Improving your muscle performance and increasing its endurance are required to protect your physical condition from ROS damaging. In recent years, much attention was paid to the suppression of oxidative reaction by food with antioxidant. Vitamin C and vitamin E have been widely used as popular elements against oxidative stress now.
The most powerful antioxidant in the carotenoid group, Astaxanthin, provides a variety of benefits to the muscle function such as improvement of physical performance, lower muscle damage and the quality of blood.
Astaxanthin for Dyspepsia and Helicobacter pylori
Dyspepsia is the general term given to a variety of digestive problems localized in the upper abdominal region. Typical symptoms for example include stomach pain, gas, acid-reflux or bloating. Dyspepsia is like the stomach version of the irritable bowel syndrome and its symptoms may appear at any age or to any gender. The medical approach to dyspepsia involves looking for treatable causes and addressing them if identified. Failing that, doctors suggest treatments by trial-and-error. The problem associated with this non-standardized approach involves drugs that may not work, may cause side effects and exacerbate the patient’s condition brought on by stressful attempts to cure symptoms. To understand the benefits of astaxanthin in dyspepsia, it is necessary to categorize specific types; most common forms are either non-ulcer dyspepsia or gastric dyspepsia. Non-ulcer dyspepsia problems usually do not have an identifiable cause, but fortunately, for most cases it is non-disease related and therefore temporary. On the other hand, gastric type dyspepsia is more severe and linked to identifiable causes. For example, the bacterial infection of Helicobacter pylori is a commonly known cause. Pathological symptoms of H. pylori infection include high levels of oxidative stress and inflammation in the stomach lining and symptoms like gastric pain and acid reflux., H. pylori can contribute to mild and severe kinds of symptoms, but on the other hand, people who are H. pylori positive can remain asymptomatic whereas others may develop into clinical problems. It is still unclear what triggers the severe form of infection and how the bacteria is passed on, but scientists suggested using strong antioxidants like astaxanthin for therapy and better long term protection.
Astaxanthin and Hypertension
Epidemiological and clinical data suggest that dietary carotenoids such as astaxanthin may protect against cardiovascular disease (CVD) which includes hypertension. This condition is associated with blood vessel dysfunction, altered contractility and tone; mediated by relaxant (nitric oxide NO; prostacyclin) and constrictor factors (thromboxane; endothelin) in the blood. Furthermore, blood flow properties serve an important role in the pathological complications seen in atherosclerosis and coronary heart disease. Research presented here suggests that astaxanthin may be useful as part of an antioxidant therapy to alleviate hypertension.
Draining the World Wealth
Diabetes mellitus is a worldwide epidemic that is critically linked to prevalence of obesity. More than 220 million people have diabetes and by the year 2030 the figures are expected to grow to 360 million. The diabetes is aggressively growing in both emerging and developed country. According to WHO, the Asian continent has over 90 million people suffering from diabetes - India (40 million) China (29 million); Indonesia (13 million) and Japan (7 million). The prevalence of diabetic patients remains pervasive in USA (22 million), Brazil (6 million), Pakistan (8 million); Russia (6 million); Italy (5 million) and Turkey (4 million). Even in the African region over 10 million people suffer from diabetes, especially in Nigeria where it is expected to reach 5 million within the year 2030.
Diabetic complications lead to heart disease (approximately 65% of death amongst diabetics), blindness, kidney failure and amputations. As a result, the indirect and direct medical expenditure of diabetics represent almost 5 times that of a non-diabetic.
Type 2 Diabetes: A Preventable Disease
In most cases, diabetes is treated with medication, although about 20% of diabetics may be managed by lifestyle changes. This means that even if we cannot change the genetic influences, fortunately, for most of us diabetes is preventable; for example, making dietary changes, taking nutritional supplements and exercising. To highlight this, people in high risk groups who achieve a 5-7% cut in body weight will reduce risk of developing diabetes approximately 58% across all age and ethnic groups.
While the debate between the contributory effects of carbohydrate and fat intake continues unabated, research reveals a strong link between foods with high glycemic index and prevalence of type 2 diabetes. Excess blood glucose needs to be converted by insulin (produced by the pancreas ß-cells) into glycogen stores, however, when glycogen stores are full, glucose is converted into fat. Over time, the body’s cells may eventually become desensitized to insulin making it necessary to produce more insulin to achieve the same affect. It is this process that would eventually lead to a state known as hyperinsulinaemic state. As a result, the body loses its ability to control high blood glucose levels (hyperglycemia) that could result in toxic conditions and promote further complications such as kidney failure.
AstaReal® was the first company in the world to commercially produce natural astaxanthin from Haematococcus pluvialis. That is why AstaREAL® products are backed by the highest expertise and longest experience in the field of microalgae research and production.
First in the World to Commercially Produce Astaxanthin from Haematococcus pluvialis
Unique and Ultra-Clean Cultivation Using Photobioreactors
AstaReal was the first company in the world to commercially produce natural astaxanthin from Haematococcus pluvialis. AstaReal has a production facility in Gustavsberg, Sweden and in Moses Lake, Washington in the United States.
Thanks to our high level of expertise and long-term experience in the production of microalgae, we can offer the best quality product with the highest amount of astaxanthin per kilogram of biomass.
The alga is grown in stainless steel photo bioreactors under carefully controlled indoor hygienic conditions to enable a more effective, cleaner, and safer process. Our equipment is of the highest quality, and the production is both ISO 9001 and HACCP certified.
Cultivation starts with the “seed” taken from a pure culture in our laboratory. The culture is then enriched with essential nutrients that provide the alga with optimal conditions for rapid growth and proliferation (Green Phase). When the culture has reached its optimum density in the Green Phase, the production of astaxanthin is induced (Red Phase). After harvest, the algae are crushed and finally spray dried.
The final biomass is a deep-red powder containing a high concentration of astaxanthin. This can then be further refined to create a high purity, raw material ingredient that is used in the manufacture of various products, such as dietary supplements, foods, and cosmetics.
We are Pioneering the Use for AstaREAL® Astaxanthin The table below summarizes the intellectual property list for the human and animal health areas for AstaREAL® Astaxanthin.
Patent Description for Human Health Patent # Agents for relieving eye controlling function error EP 1396264 Oral preparation for the prophylactic and therapeutic treatment of Helicobacter sp. infection US 6262316 Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases US 6245818 Use of xanthophylls for improvement of duration of muscle function or treatment of muscle disorders CA 2299366 Method of increasing the production and improving the quality of semen US 6410602 Method of the prophylactic treatment of mastitis US 6335015 Treatment of dyspepsia US 6923967 Use of xanthophylls, astaxanthin e.g., for treatment of autoimmune diseases, chronic viral and intracellular bacterial infections US 6773708 Method of inhibiting the expression of inflammatory cytokines and chemokines US 078040 Composition for body fat reduction JP 5165894
Patent Description for Animals Patent # Method for increasing the production of/in breeding and production animals in the poultry industry US 5744502 Agent for increasing the production of/in breeding and production mammals US 6054491 Approved Patent Description for Device and Chemical Products Patent # Fine algae culture device US 6348347 Method of preventing discoloration of carotenoid pigment and container used therefor EP 2322579 (as of July 2013
Our Commitment to Safety
Natural astaxanthin, either as a purified Haematococcus pluvialis extract or in algal biomass, has been evaluated in multiple studies to determine its potential for adverse effects and genotoxicity. The study type, study design, test materials, and findings are summarized in the tables on the following pages.
AstaREAL® - The Most Studied Brand of Astaxanthin
The best source of natural astaxanthin is Haematococcus pluvialis microalgae, which naturally produces astaxanthin as part of its life cycle. The vast majority of the studies and research demonstrating the safety and efficacy of astaxanthin in humans have been performed by using natural astaxanthin from microalgae. Natural astaxanthin from microalgae has been on the market as a nutritional supplement for more than 15 years with no reports of adverse side effects. We have long been at the forefront of research, development, and production of natural astaxanthin from Haematococcus pluvialis microalgae.
AstaREAL® and Clinical Studies
The clinical database for AstaREAL® as of 2013 contains 48 human studies, including 23 double-blind, placebo-controlled trials, with more than 1,400 participants undergoing treatments lasting from 2 weeks to 6 months. The doses used in these trials ranged from 2 to 45 mg/day. The trials were designed to determine the efficacy, safety, and tolerance of AstaREAL® astaxanthin for different doses, treatment periods, study designs, and demographic variables including age, gender, and ethnicity. All studies revealed no adverse effects based on hematological findings, serum chemistry, urinal analysis, and self-report questionnaires. A summary of clinical trial designs, doses, and adverse effects in these studies is presented in Tables 1 and 2.
In a double-blind, placebo-controlled study conducted in Japan in 2010, 15 healthy adults took 45 mg/day of AstaREAL® astaxanthin for 4 weeks, which was over 7-fold the suggested dose of 6 mg/day. The study revealed no adverse effects for all standard examination parameters, including intraocular pressure (Kajita et al., 2010).
In 2010, AstaREAL® astaxanthin esters extracted from Haematococcus pluvialis microalgae attained Generally Recognized as Safe (GRAS) status with successful U.S. Food and Drug Administration (FDA) notification, further demonstrating its safety for human use and consumption.
The specifications of AstaREAL® astaxanthin are recognized as the international reference standard for astaxanthin esters derived from the microalgae Haematococcus pluvialis in the authoritative Food Chemicals Codex (8th edition), published by U.S. Pharmacopeial Convention in 2012.
AstaREAL: Acute and Subchronic Toxicity Tests
The non-clinical toxicological study database for AstaREAL® includes 5 trials ranging from single-dose to 90-day subchronic toxicity studies. The doses used in these trials ranged from 2 to 360 mg/kg. All studies revealed no adverse effects. A summary of the study designs, doses, and safety results is presented in Tables 3 and 4. An in vitro micronucleus test was conducted on mice after they were given a single dose of 2,000 mg/kg of AstaREAL® (Takahashi et al., 2010). The study showed no adverse effects on body weight and appearance. Genotoxicity tests showed no evidence of mutagenicity in Ames Salmonella mutagenicity assays. Furthermore, a subsequent in vitro study showed no induction of chromosome aberration or mutagenic effects. A teratology study showed that rabbits given a dose of 400 mg/kg exhibited no maternal embryotoxic or teratogenic effects over the gestational period.
AstaREAL®: Safety Summary
A comprehensive set of clinical and non-clinical studies constitute a sufficient database for evaluating the potential toxicity of astaxanthin in extracts or algal biomass. The lack of any findings of toxicity from any study on astaxanthin shows that it is safe when used as recommended.
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2. Choi HD et al., Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother Res: PTR. 2011;25(12):1813-18.
3. Yoshida H et al., Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. 2010;209(2):520-23.
4. Iwabayashi M et al., Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. Anti-aging medicine. 2009;6(4):15-21.
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9. Saito M et al., Astaxanthin increases choroidal blood flow velocity. Graefes Arch Clin Exp Ophthalmol. 2012;250:239-45.
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17. Satoh A et al., Effects of the lntake of astaxanthin on the reduction of skin darkling induced by uv irradiation in adult women. Oyo Yakuri Pharmacometrics. 2011;80(1/2):7-11.
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23. Stahl W et al., Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr. 2000;71(3):795-8.
24. Earnest CP et al., Effect of astaxanthin on cycling time trial performance. Int J Sports Med. 2011;32(11):882-88.
25. Malmsten CL et al., Dietary supplementation with astaxanthin-rich algal meal improves strength endurance - A double blind placebo controlled study on male students -. Carotenoid Science. 2008;13:20-22.
26. Aoi W et al., Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun. 2008;366(4):892-97.
27. Fukamauchi M et al., Food functionality of astaxathin-10: Synergistic effects of astaxanthin intake and aerobic exercise. Food Style 21. 2007;11:1-4.
28. Ikeuchi M et al., Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol Pharm Bull. 2006;29(10):2106-10.
29. Aoi W et al., Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 2003;5(1):139-44.
30. Sawaki K et al., Sports performance benefits from taking natural astaxanthin Characterized by visual acuity and muscular fatigue improvement in humans. J Clin Ther Med 2002;18(9):1085-100.
31. Bennedsen M, Wang X, Willen R. Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunol Lett. 1999. 70: 185-189.
32. Kupcinskas L, Lafolie P, Lignell A, Kiudelis G, Jonaitis L, Adamonis K, Andersen LP, Wadstrom T. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study. Phytomedicine 2008. 15: 391-399.
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34. Wang X, Willen R, Wadstrom T. Astaxanthin rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob Agents Chemother. 2000. 44: 2452-2457.
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39. Iwabayashi M, Fujioka N, Nomoto K, Miyazaki R, Takahashi H, Hibino S, Takahashi Y, Nishikawa K, Nishida M, Yonei Y. (2009). Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. J. Anti Aging Med., 6 (4):15-21.
40. Kudo Y, Nakajima R, Matsumoto N. (2002). Effects of astaxanthin on brain damages due to ischemia. Carotenoid Science (5):25.
41. Li W, Hellsten A, Jacobsson LS, Blomqvist HM, Olsson AG, Yuan XM. (2004). Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits. J. Mol. Cell. Cardio., 37(5):969-978.
42. Miyawaki H, Takahashi J, Tsukahara H, Takehara I. (2005). Effects of astaxanthin on human blood rheology. J. Clin. Thera. Med., 21(4):421-429.
43. Preuss H, Echard B, Bagchi D, Perricone VN, Yamashita E. (2009). Astaxanthin lowers blood pressure and lessens the activity of the renin-angiotensin system in Zucker Fatty Rats. J. Funct. Foods, I:13-22.
44. Iwabayashi M, Fujioka N, Nomoto K, Miyazaki R, Takahashi H, Hibino S, Takahashi Y, Nishikawa K, Nishida M, Yonei Y. (2009). Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. J. Anti Aging Med., 6 (4):15-21.
45. Manabe E, Handa O, Naito Y, Mizushima K, Akagiri S, Adachi S, Takagi T, Kokura S, Maoka T, Yoshikawa T. (2008). Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. J. Cellular Biochem. 103 (6):1925-37.
46. Naito Y, Uchiyama K, Aoi W, Hasegawa G, Nakamura N, Yoshida N, Maoka T, Takahashi J, Yoshikawa T. (2004) Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. BioFactors 20:49-59. Nutritional Outlook April. "Fighting Diabetes"
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48. Preuss H, Echard B, Bagchi D, Perricone VN, Yamashita E. (2009). Astaxanthin lowers blood pressure and lessens the activity of the renin-angiotensin system in Zucker Fatty Rats. J. Funct. Foods, I:13-22.
49. Uchiyama K, Naito Y, Hasegawa G, Nakamura N, Takahashi J, Yoshikawa T. (2002). Astaxanthin Protects ß-cells against glucose toxicity in diabetic db/db mice. Redox Rep., 7(5):290-293.
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