Augusta Chronicle Friday, October 29, 2004, Associated Press!
How many people have gotten home after a blindingly stressful day and realize that they've forgotten some important event or errand? Well now at least there's a scientific explanation for the oversight. Stress makes you forgetful. People going on-stage, taking an exam or finding themselves in similarly tough situations probably already knew this, of course. But a team of researchers has found how it happens, a discovery that they say could point the way to better treatments for such illnesses as schizophrenia and bipolar disorder. Stressful situations in which the individual has no control were found to activate an enzyme in the brain called protein kinase C, which impairs the short-term memory and other functions in the prefrontal cortex, the executive-decision part of the brain, says Dr. Amy F.T. Arnsten of Yale Medical School.
The findings were reported Thursday in the journal Science. The PKC enzyme is also active in bipolar disorder and schizophrenia, and Dr. Arnsten notes that a first psychotic episode can be precipitated by a stressful situation, such as going away to college for the first time or joining the military. By affecting that part of the brain, the researchers say, PKC could be a factor in the distractability, impulsiveness and impaired judgment that occurs in those illnesses. The finding that uncontrolled stress activates PKC indicates a possible new direction for treatments - seeking drugs that inhibit PKC, Dr. Arnsten said. "These new findings may also help us understand the impulsivity and distractibility observed in children with lead poisoning," she said. "Very low levels of lead can activate PKC, and this may lead to impaired regulation of behavior."
The researchers used chemicals to induce stress in rats and monkeys because the stress levels are easily controlled, Dr. Arnsten said. It was similar to humans exposed to loud noise or panicking before an exam, she said. "It doesn't have to be traumatic, as long as you feel out of control," she said. "Control is the essential factor. If you are confident you don't have these problems." PKC affects a part of the brain that allows abstract reasoning, using working memory that is constantly updated. "This kind of memory, the ability to concentrate, seems to be impaired when exposed to mild stresses," she said. Scientists think the effect evolved as a protective mechanism in the event of danger, she said.
Commentary by Dr. Vickery!
The pieces of the "jigsaw puzzle" continue to fall rapidly in place with Platinum Plus in the core of life.
- The clearing of "Brain Fog" in our treatment of fibromyalgia.
- Improved positive attitude is a constantly observed change in persons first taking Platinum Plus Amino Acids.
- Neurotransmitter production and balancing is promoted by Platinum Plus Amino Acids.
- Lead and other toxic minerals are easily removed with Platinum Plus Amino Acids.
- Stress effects are relieved with Platinum Plus Amino Acids.
- Glutathione and metallothionein (discovered in 1999) are some of the mechanisms and built from amino acids.
- Mental control has been observed in previously unstable persons with Platinum Plus Amino Acids.
Brice E. Vickery, D.C. (retired)
President, SuperNutrient Corporation