Magnesium and Radiation Protection
by Dr. Mark Sircus, Ac., OMD, DM (P)
Director International Medical Veritas Association
Doctor of Oriental and Pastoral Medicine
It is in a list of medicinals that prevent and treat cancer that we find helpful substances that treat and strengthen us against radiation contamination.
“In the years leading up to Chernobyl, some dairy farmers in Austria were using remineralization as a part of their operations. They added rock dust to liquid manure as well as combining it with compost, thereby removing odors and greatly increasing soil biota. As a result, cows had twice the normal lifespan and produced much more milk. Amazingly enough, after Chernobyl, the cheeses that were remineralized (as well as biodynamic cheeses) measured no radioactivity whatsoever. Austrians would stand in long lines in order to buy these safe, remineralized products” writes Joanna Campe.
Iodine is obviously not the only substance that we should run to in the face of increasing radiation threats. Magnesium is a vital mineral whose lack leaves us open to not only radioactive damages but also those from heavy metals and thousands of chemicals,which we are commonly exposed to. Mercury and now a long list of radioactive particles are floating in the environment like invisible clouds that have spread out everywhere. They are raining down on us, damaging and damning our future. We can no longer be passive about building our defenses against the toxic onslaught.
Without sufficient magnesium, the body accumulates toxins and acid residues, degenerates rapidly, and ages prematurely.
Just about everyone who is writing protocols for radiation toxicity is forgetting about the importance of magnesium salts. Worse still are governments and the entire institution of medicine that are purposely ignorant about magnesium, so they cannot possibly be trusted for valuable health and medical information that will help us in our time of dire need. The need was dire before Fukushima but they did not want to admit that; they let the public get obsessed with CO2 emissions and said nothing about the mercury. Now with radioactive nucleides steadily building up in the background, we are in trouble than any of us care to admit.
Today the situation has gone nuclear and there has never before been a need so great for detoxification and chelation. Magnesium is a crucial factor in the natural self-cleansing and detoxification responses of the body. Magnesium is also necessary for effective chelation. It stimulates the sodium potassium pump on the cell wall and this initiates the cleansing process in part because the sodium-potassium-ATPase pump regulates intracellular and extracellular potassium levels. The healthy cell wall favors intake of nutrients and elimination of waste products.
The involvement of free radicals in tissue injury induced by magnesium deficiency  causes an accumulation of oxidative products in heart, liver, kidney, skeletal muscle tissues and in red blood cells,  leaving them more vulnerable to oxidative stress caused by radiation exposure. Both radiation exposure and heavy metals produce oxidative stress through the creation of increased levels of reactive oxygen species (ROS-oxygen free radicals, peroxides, and singlet oxygen). It is known that these increased levels of intracellular ROS are sufficient to trigger apoptosis (cell death).
Glutathione is Magnesium-Dependent
Glutathione protects the cells from oxidative-stress-induced apoptosis and glutathione levels are magnesium dependent! “Glutathione is a very important detoxifying agent, enabling the body to get rid of undesirable toxins and pollutants. It forms a soluble compound with the toxin that can then be excreted through the urine or the gut. The liver and kidneys contain high levels of glutathione as they have the greatest exposure to toxins. The lungs are also rich in glutathione partly for the same reason. Many cancer-producing chemicals, heavy metals, drug metabolites etc. are disposed of in this way,” says Dr. Patricia Kongshavn, former professor, department of medicine at McGill University.
Glutathione is a polypeptide, C10H17N3O6S, of glycine, cysteine, and glutamic acid.
Glutathione synthetase requires -glutamyl cysteine, glycine, ATP, and magnesium ions to form glutathione.  In magnesium deficiency, the ss y-glutamyltranspeptidase is lowered.  There is a direct relationship between cellular magnesium, GSH/GSSG ratios, and tissue glucose metabolism.  Magnesium deficiency causes glutathione loss and this is unwelcome as the clouds of radiation are touching down across the northern hemisphere. Magnesium deficiency causes glutathione loss, which is not at all healthy because glutathione helps to defend the body against damage from cigarette smoking, exposure to radiation, cancer chemotherapy, and toxins such as alcohol and just about everything else.
According to Dr. Russell Blaylock, low magnesium is associated with dramatic increases in free radical generation as well as glutathione depletionand this is vital since glutathione is one of the few antioxidant molecules known to neutralize mercury.  “For every molecule of pesticide that your body detoxifies, you throw away or use up forever a molecule of glutathione, magnesium and more,” says Dr. Sherry Rogers who goes on to say that, “Your body uses nutrients to make this glutathione and it uses up energy as well. Every time we detoxify a chemical, we use up, lose, throw away forever, a certain amount of nutrients.”
Deficiencies in basic minerals like magnesium and selenium can make all the difference between health and disease, between being able to withstand chemical, heavy metal and radiation exposure. Dr. Rogers has indicated that there is as much as a 500-fold difference in the ability of individuals to detoxify the same chemicals and much of that will be true for radiation as well. A key marker of this difference is each individual’s magnesium level. Deficiencies in magnesium will wreak havoc with our body’s ability to detoxify and chelate heavy radioactive particles and explains much of the difference between one person withstanding radiation exposures and another person falling to radiation sickness.
Dr. Leslie Fisher has treated in excess of 35,000 patients where mineral therapy was prescribed as the sole form of medication. He has conducted research within his own clinics and the Department of Psychiatry, Austin Hospital, Melbourne. Mineral therapy is the foundation upon which chelation  treatments and protocols are built. Magnesium does protect cells from aluminum, mercury, lead, cadmium, beryllium and nickel, which explains why re-mineralization is so essential for heavy metal detoxification and chelation as well as radiation protection. Magnesium is essential for the survival of our cells but takes on further importance now where our bodies are being bombarded on a daily basis with heavy metals and radiation.
Radiation and Diabetes
No one is going to convince the public that the increasing radiation will have a general effect on our health that can be easily traced back to the source. Even before we get cancer from radiation we have a general down-spiraling of body functions because of all the oxidative stress. In my book, New Paradigms in Diabetes, I write extensively about the direct relationship between magnesium deficiency and the onset of diabetes. Pancreatic beta cells are sensitive to reactive oxygen species (ROS)  attack when they are exposed to oxidative stress,  because of the relatively low expression of antioxidant enzymes such as catalase and glutathione peroxidase. 
Diabetes is typically accompanied by increased production of free radicals and/or impaired antioxidant defense capabilities, indicating a central contribution of reactive oxygen species. It is also a fact that ROS is one of the major factors that induce oxidative modification of DNA and gene mutation.  The Chernobyl incident was a major disaster of humanity, which has resulted in a plethora of health problems that are still far from being fully recognized. Most studies analyzing the medical consequences of this catastrophe have so far focused on diseases such as thyroid cancer, leukemia, immune and autoimmune pathology   even though an increase in the incidence of type 1 diabetes mellitus, a disorder involving the immune system, was observed within the residential population of Hiroshima among survivors of the atom bomb detonation. 
Studies have also shown that thymectomy and a sub-lethal dose of gamma radiation induces type 1 diabetes in rats.  Researchers at the Pediatric Hospital A. Meyer, Florence, Italy studied this question by assessing the incidence of the disease in children in Gomel, Belarus in the years subsequent to the Chernobyl disaster. The results of the study seem to confirm the hypothesis that environmental pollution such as that subsequent to the Chernobyl accident can cause diabetes.  Mass screening for diabetes mellitus has been conducted on 64,000-113,000 atomic bomb survivors residing in Hiroshima City since 1961. From 1971 to 1992 a 2.7-fold increase in the prevalence of diabetes mellitus was observed in males and a 3.2-fold increase in females. 
We have a significant and documented increase in the incidence of type 1 diabetes in children and adolescents after Chernobyl in the radioactively contaminated area of Gomel compared to Minsk.
Heinrich Heine University
When beginning to build a protocol against the radiation and heavy metal onslaught, we need to stick with the basics and they are magnesium, iodine, sodium bicarbonate, vitamin C, selenium, clay, THC (cannabis), as well as a natural chelator and superfoods. Properly filtered water also is essential. There is always more we can do but even affording these basics is a challenge to many.
Special Note: One of my readers wrote saying, “Thank you for the labor of love you’ve given to the inhabitants of the world. All the information about magnesium, iodine, baking soda, etc. is priceless and very much appreciated. I know we can’t thank you enough for your generosity with the knowledge you’ve accumulated from all of your research. I know you’ve had your detractors-ignore them!” These basic medicines are not only the mainstay of emergency rooms and intensive care wards but are the backbone of a my new form of medicine called Natural Allopathic Medicine, which makes sense in the age of toxicity that we all have live in.
 Magnesium deficiency (MgD) has been associated with production of reactive oxygen species, cytokines, and eicosanoids, as well as vascular compromise in vivo. Although MgD-induced inflammatory change occurs during “chronic” MgD in vivo, acute MgD may also affect the vasculature and consequently, predispose endothelial cells (EC) to perturbations associated with chronic MgD. As oxyradical production is a significant component of chronic MgD, we examined the effect of acute MgD on EC oxidant production in vitro. In addition we determined EC; pH, mitochondrial function, lysosomal integrity and general cellular antioxidant capacity. Decreasing Mg2+ (< or = 250microM) significantly increased EC oxidant production relative to control Mg2+ (1000 microM). MgD-induced oxidant production, occurring within 30 min, was attenuated by EC treatment with oxyradical scavengers and inhibitors of eicosanoid biosynthesis. Coincident with increased oxidant production were reductions in intracellular glutathione (GSH) and corresponding EC alkalinization. These data suggest that acute MgD is sufficient for induction of EC oxidant production, the extent of which may determine, at least in part, the extent of EC dysfunction/injury associated with chronic MgD. Effect of acute magnesium deficiency (MgD) on aortic endothelial cell (EC) oxidant production. Wiles ME, Wagner TL, Weglicki WB.The George Washington University Medical Center, Division of Experimental Medicine, Washington, D.C., USA.[email protected] Life Sci. 1997;60(3):221-36.
 Martin, Hlne. Richert, Lysiane. Berthelot, Alain Magnesium Deficiency Induces Apoptosis in Primary Cultures of Rat Hepatocytes. Laboratoire de Physiologie, et Laboratoire de BiologieCellulaire, UFR des Sciences Mdicales et Pharmaceutiques, Besanon, France. 2003 The American Society for Nutritional Sciences J. Nutr. 133:2505-2511, August 2003.
 Virginia Minnich, M. B. Smith, M. J. Brauner, and Philip W. Majerus. Glutathione biosynthesis in human erythrocytes. Department of Internal Medicine, Washington University School of Medicine, J Clin Invest. 1971 March; 50(3): 507-513. Abstract: The two enzymes required for de novo glutathione synthesis, glutamyl cysteine synthetase and glutathione synthetase, have been demonstrated in hemolysates of human erythrocytes. Glutamyl cysteine synthetase requires glutamic acid, cysteine, adenosine triphosphate (ATP), and magnesium ions to form a-glutamyl cysteine. The activity of this enzyme in hemolysates from 25 normal subjects was 0.430.04 ?moleglutamyl cysteine formed per g hemoglobin per min. Glutathione synthetase requires ?-glutamyl cysteine, glycine, ATP, and magnesium ions to form glutathione. The activity of this enzyme in hemolysates from 25 normal subjects was 0.190.03 ?mole glutathione formed per g hemoglobin per min. Glutathione synthetase also catalyzes an exchange reaction between glycine and glutathione, but this reaction is not significant under the conditions used for assay of hemolysates. The capacity for erythrocytes to synthesize glutathione exceeds the rate of glutathione turnover by 150-fold, indicating that there is considerable reserve capacity for glutathione synthesis. A patient with erythrocyte glutathione synthetase deficiency has been described. The inability of patients’ extracts to synthesize glutathione is corrected by the addition of pure glutathione synthetase, indicating that there is no inhibitor in the patients’ erythrocytes.
 Braverman, E.R. (with Pfeiffer, C.C.)(1987). The healing nutrients within: Facts, findings and new research on amino acids. New Canaan: Keats Publishing.
 Barbagallo, M. et al. Effects of glutathione on red blood cell intracellular magnesium: relation to glucose metabolism. Hypertension. 1999 Jul;34(1):76-82. Institute of Internal Medicine and Geriatrics, University of Palermo, Italy.[email protected]
 Chelation is a recognized treatment for heavy metal poisoning (such as lead and mercury)
 ROS (Reactive Oxygen Species) are natural byproducts of oxygen metabolism in the body. Free radicals and other byproducts are formed as a result of this metabolism, and at lower levels can be very beneficial, but when too many of these byproducts are formed the situation of oxidative stress occurs. Reactive oxygen species (ROS) include oxygen ions, free radicals and peroxides both inorganic and organic. They are generally very small molecules and are highly reactive due to the presence of unpaired valence shell electrons. Oxidative stress is a medical term for damage to animal or plant cells (and thereby the organs and tissues composed of those cells) caused by excesses of these reactive oxygen species, which include (but are not limited to) superoxide, singlet oxygen, peroxynitrite or hydrogen peroxide. Superoxide is produced deleteriously by 1-electron transfers in the mitochondrial electron transfer chain. It is defined as an imbalance between pro-oxidants and anti-oxidants, with the former prevailing. The causes of these excesses are many, and include environmental influences of every type. Enzyme activities are sometimes affected negatively, leading to greater production of excess ROS, and heavy metals such as chromium, vanadium, and others are said to be involved, now this new evidence that methylmercury definitely plays a significant role in the pancreas. Cells are normally able to defend themselves against ROS damage through the use of enzymes such as superoxide dismutases and catalases. Small molecule antioxidants such as Ascorbic acid (vitamin-C), uric acid, and glutathione also play important roles as cellular antioxidants. Similarly, Polyphenol antioxidants assist in preventing ROS damage by scavenging free radicals. Studies are conflicting on some antioxidants such as Vit. E. The resulting inflammatory processes are believed to be the result of these ROS excesses and include cardiovascular disease, ALS, neurodegenerative diseases, and many others.
 Kajimoto, Y., and Kaneto, H. (2004) Role of oxidative stress in pancreatic beta-cell dysfunction. Ann. N. Y. Acad. Sci. 1011, 168-176.
 Tiedge, M., Lortz, S., Drinkgern, J., and Lenzen, S. (1997) Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46, 1733-1742.
 Inoue, M., Sato, E. F., Nishikawa, M., Hiramoto, K., Kashiwagi, A., and Utsumi, K. (2004) Free radical theory of apoptosis and metamorphosis.Redox Rep. 9, 237-247.
 Kuzmenok O, Potapnev M, Potapova S et al. (2003) Late effects of the Chernobyl radiation accident on T cell-mediated immunity in cleanup workers. Radiat Res 159: 109-116.
 Lomat L, Galburt G, Quastel MR, Polyakov S, Okeanov A, Rozin S (1997) Incidence of childhood disease in Belarus associated with the Chernobyl accident. Environ Health Perspect [Suppl 105] 6:1529-1532.
 Ito C (1994) Trends in the prevalence of diabetes mellitus among Hiroshima atomic bombsurvivors. Diabetes Res ClinPract [Suppl]:S29-S35.
 Ramanathan S, Bihoreau MT, Paterson AD, Marandi L, Gauguier D, Poussier P (2002) Thymectomy and radiationinduced type 1 diabetes in nonlymphopenic BB rats. Diabetes 51:2975-2981.
 J PediatrEndocrinolMetab. 2002 Jan;15(1):53-7. Incidence of childhood type 1 diabetes mellitus in Gomel, Belarus.Martinucci ME, Curradi G, Fasulo A, Medici A, Toni S, Osovik G, Lapistkaya E, Sherbitskaya E. Regional Centre for Juvenile Diabetes, Paediatric Hospital A. Meyer, Florence, Italy.
 Trends in the prevalence of diabetes mellitus among Hiroshima atomic bomb survivors. Diabetes Res ClinPract. 1994 Oct;24 Suppl:S29-35. Hiroshima Atomic Bomb Casualty Council, Health Management Center, Japan.