Pantethine (as Pantesin)
Pantesin supplementation showed a significant improvement in blood lipid ratios over and above the heart healthy diet!
Pantesin is a branded form of Pantethine, with 35+ years of research supporting its positive effect on cholesterol levels in high-risk cardiovascular disease (CVD) subjects.
A derivative of B5, pantethine is composed of two molecules of pantothenic acid linked by cysteamine bridging groups. Pantethine helps increase the metabolic activity of Coenzyme A (CoA) and the acyl-carrier protein (ACP), which creates a reduction in cholesterol synthesis.
Two Studies, Researching the Effectiveness of Pantethine (1)
Overview of all published studies from 1966-2002 on subjects with abnormally elevated lipid levels, who were given an average of 900 mg/day of Pantesin.
Results at 4 months:
8% increase in HDL (good) cholesterol
20% decrease in LDL (bad) cholesterol
33% decrease in Triglycerides
For both studies on low to moderate CVD risk subjects, the subjects consumed the U.S. National Institutes of Health "Heart Healthy Diet" for four weeks, to establish a baseline, then maintained the diet for the 16 week study period.
Study No. 1 Results (2)
After two weeks, taking 600 mg of Pantesin a day, the subjects averaged a reduction of 3% in total cholesterol, 4% in LDL (bad) cholesterol, and 5% in Apolipoprotein B (main component of LDL).
A significant improvement in blood lipid ratios - over and above the Heart Healthy Diet!
Study No. 2 Results (3)
Low to moderate cardiovascular-disease-risk subjects, who were eligible for statin therapy, showed a significant decrease of 6% in total cholesterol, 11% in LDL (bad) cholesterol, and 7% in non-HDL cholesterol - significant.
Results also showed:
- No additional measurable benefits when Pantesin was increased from 600 to 900 mg/day for weeks 9-16
- No statistical difference in subjects blood CoQ10 levels
- No significant adverse events compared to placebo.
Patented formula made from natural citrus and palm fruit extracts, combining polymethoxylated flavones (PMFs), delta, gamma, and alpha tocotrienols.
Sytrinol and Placebo Controlled Study
Published placebo controlled, double-blind, randomized, peer reviewed research shows that Sytrinol supports healthy blood lipid levels in as little as 12 weeks. Results show a 72% reduction in cholesterol levels with Sytrinol supplementation, compared to a placebo after 12 weeks.
1. McRae MP et. al., Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability, Nutrition Research, 25:319-333, 2005
2. Rumberger JA et al., Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011 Aug 31.
3. Evans M. et al., Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014 Feb 27.